Histone Content of Chromosomal Loci Active and Inactive in Rna Synthesis
نویسندگان
چکیده
It has been reported that histones inhibit DNAdependent RNA synthesis in vitro (5, 15) and these results have been taken as support of the hypothesis (34) that histones function as regulators of gene activity in vivo. One necessary correlate of this hypothesis is that different cell types contain different amounts and/or different kinds of histones or that the histone-DNA interactions differ in different tissues. However, biochemical analyses have not conclusively demonstrated tissue specificity of histones (18). This is perhaps due to
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عنوان ژورنال:
- The Journal of Cell Biology
دوره 33 شماره
صفحات -
تاریخ انتشار 1967